Macro- and microtranscriptomic evidence of the monocyte recruitment to regenerating liver after partial hepatectomy in mouse model

Macrophages are important regulators of liver repair. Participation of migratory monocytes/macrophages in regeneration of hepatic tissues after resection remains disputable. In mouse the resection promotes migration of Ly6C+CD11b+ monocytes/macrophages to the remnant liver accompanied by a reduction in its CD206 + macrophage content. Macrophage proliferation within the liver reaches maximum on day 3 after the surgery. Corresponding macro- and microtranscriptomic profiles of macrophages in regeneration liver cannot be unambiguously defined as pro- or anti-inflammatory. Their typical features include elevated expression of leukocyte chemoattractant factors, and many of the differentially expressed sequences are related to the control of cell growth and metabolic processes in the liver. These findings revealed essential roles of immigration of monocytes/macrophages and macrophages proliferation in maintenance of macrophage populations in the mouse liver during its recovery from a massive resection. © 2021 The Authors

Авторы
Elchaninov A. 1, 3 , Nikitina M. 2 , Vishnyakova P. 1, 3 , Lokhonina A. 1, 3 , Makarov A. 1, 4 , Sukhikh G.1 , Fatkhudinov T. 3, 2
Издательство
Elsevier Masson SAS
Язык
Английский
Статус
Опубликовано
Номер
111516
Том
138
Год
2021
Организации
  • 1 Laboratory of Regenerative Medicine, FSBI National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, Moscow, 117997, Russian Federation
  • 2 Laboratory of Growth and Development, FSBSI Scientific Research Institute of Human Morphology, Moscow, 117418, Russian Federation
  • 3 Histology Department, Medical Institute, Peoples' Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
  • 4 Histology Department, Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, Moscow, 117997, Russian Federation
Ключевые слова
Liver; Macrophage; MicroRNA; Monocyte; NanoString; Regeneration
Дата создания
20.04.2021
Дата изменения
16.11.2021
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/71968/
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