Empirical therapy for vulvovaginitis in reproductive-aged women in routine clinical practice

Objective. To evaluate the efficiency of empirical therapy with tergynan in reproductive-aged women in routine clinical practice. Subjects and methods. The TERRA multicenter post-registration observational study enrolled 430 reproductive-aged patients diagnosed with acute vulvovaginitis. Based on their complaints, clinical symptoms, and objective examination, the patients received empirical therapy with the combination antimicrobial drug Tergynan as a single vaginal tablet once daily for 10 days. Gynecological examination, pH-metry, and bacterioscopic and bacteriological examinations of discharge (Femoflor-16) were performed, and the time course of changes in clinical symptoms evaluated. Results. There was less vaginal discharge, a complete disappearance of unpleasant odor, and a feeling of vaginal itching and burning (74.5 and 67.1%, respectively). There were increases in the detection rate of Lactobacillus spp. by 2 times with a dissemination level of 106-107 CFU/ml, in the suppression of obligate anaerobic representatives (associations of Gardnerella vaginalis + Prevotella bivia + Porphyromonas spp., as well as Eubacterium spp.) by 5 times, facultative anaerobic bacteria (Enterobacteriaceae and Streptococcus spp.) by 3 times, and yeast-like fungi of the genus Candida by 2 times. Conclusion. This investigation demonstrated the high clinical (96.5%) and microbiological (97.3%) efficiency of empirical therapy with tergynan in 430 reproductive-aged women with acute nonspecific vulvovaginitis. © 2020, Bionika Media Ltd. All rights reserved.

Radzinsky V.E. 1 , Anufrieva V.G.2 , Belinina A.A.3 , Bespalaya A.V.4 , Dolgushina V.F.5 , Zhilno E.Y.U.6 , Zazerskaya I.E.7 , Katkova N.Y.U.8 , Klimova O.I. 1 , Korotkikh I.N. 9 , Kravchenko E.N.10 , Kutsenko I.G.11 , Lebedenko E.Y.2 , Loseva V.V.12 , Mingaleva N.V.13 , Molchanova I.V.3 , Ordiyants I.M. 1 , Padrul M.M.14 , Pashov A.I.12 , Protopopova N.V.15 , Rosyuk E.A.16 , Rymashevsky M.A.2 , Sablina N.V.17 , Salov I.A.6 , Sokolova T.M.18 , Spiridonova N.V.19
ООО «Бионика Медиа»
Номер выпуска
  • 1 Peoples’ Friendship University of Russia, Miklukho-Maklaya str, 6, Moscow, 117198, Russian Federation
  • 2 Rostov State Medical University, per. Nahichevanskiy, 29, Rostov-on-Don, 344022, Russian Federation
  • 3 Altai Territorial Clinical Perinatal Center, Altayskiy kray, ul. Fomina, 154, Barnaul, Russian Federation
  • 4 Rostov Perinatal Center, Bodraya st, 90, Rostov-on-Don, 344068, Russian Federation
  • 5 South Ural State Medical University, ul. Vorovskogo, 15V, Chelyabinsk, 454092, Russian Federation
  • 6 V.I. Razumovsky Saratov State Medical University, Volga Federal District, Saratov Region, ul. Big Cossack, 112, Saratov, Russian Federation
  • 7 V.A. Almazov National Medical Research Center, ul. Akkuratova, 2, St. Petersburg, 197341, Russian Federation
  • 8 Volga Research Medical University, pl. Minin and Pozharsky, d10 / 1, Nizhny Novgorod, 603005, Russian Federation
  • 9 N.N. Burdenko, Voronezh Medical University, Moskovsky pr., 151, Voronezh, 394066, Russian Federation
  • 10 Omsk State Medical University, Оmsk region, Lenina ul, 12, Omsk, 644099, Russian Federation
  • 11 Siberian State Medical University, Моscow tract, 2, Томsk, 634050, Russian Federation
  • 12 Immanuel Kant Baltic Federal University, Kaliningrad region, al. Kashtanov, 145, Kaliningrad, 236023, Russian Federation
  • 13 Kuban State Medical University, st. Red Partisans, 6, Krasnodar, 350012, Russian Federation
  • 14 Academician E.A. Vagner Perm State Medical University, Petropavlovskaya St 26, Perm, 614000, Russian Federation
  • 15 Irkutsk State Medical University, m/r Yubileyniy, 100, Irkutsk, 664079, Russian Federation
  • 16 Ural State Medical University, ul. Repina, 3, Yekaterinburg, 620028, Russian Federation
  • 17 S.P. Botkin City Clinical Hospital, 2nd Botkinsky Prospect, 5, Moscow, 125284, Russian Federation
  • 18 Novosibirsk State Medical University, Siberian Federal District, Novosibirsk Region, Krasny prospect, 130, Novosibirsk, 630087, Russian Federation
  • 19 Samara State Medical University, ul. Polevaya 80, Samara, 443099, Russian Federation
Ключевые слова
Acute nonspecific vulvovaginitis; Antibiotic resistance; Empirical therapy; Reproductive age
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