Personified tactics of treatment of female patients with early forms of pelvic organ prolapse in the reproductive age
The objective. Development of a personified tactics of treatment of female patients with early forms of pelvic organ prolapse (POP) in the reproductive age. Patients and methods. The study included 240 women with POP-Q (I-II)) aged 28 to 42 years; 70 healthy women comprised the control group. Patients with POP were divided into 2 groups. Group 1 underwent surgical treatment of POP, group 2 received conservative therapy. Later on, groups of effective and ineffective treatment were singled out. Results. In patients with POP, phenotypic signs of hereditary disorders were noted in 75% of cases, in the control group-in 38%. All women with POP had signs of the pelvic floor damage, found by ultrasound examination. The incidence of point mutations of NAT-2 gene in patients with early forms of POP is significantly higher in the group of women whose treatment was ineffective, 29 (65.9%) vs. 11 (30.6%) patients from the effective treatment group. Based on the obtained data, we have constructed a scale of predicting risks of relapse and progression of POP and developed an algorithm of treatment of patients with POP-Q (I-II) after labour. Conclusion. The use of the algorithm will permit to avoid development of subsequent complications of surgical treatment, and also to reduce the number and severity of relapses in female patients of reproductive age.