Astra Salvensis.
Transilvanian Association for the Literarure and Culture of Romanian People (ASTRA).
Том 6.
2018.
С. 753-766
The sequential three-component reaction between o-hydroxybenzaldehydes, N-(cyanomethyl)pyridinium salts and a nucleophile towards substituted chromenoimidazopyridines under oxidative conditions has been developed. The employment of Mn(OAc)3•2H2O or KMnO4 as stoichiometric oxidants allowed the use of a wide range of nucleophiles, such as nitromethane, (aza)indoles, pyrroles, phenols, pyrazole, indazole and diethyl malonate. The formation of the target compounds presumably proceeds through a domino Knoevenagel/cyclization/Michael addition/oxidative cyclization reaction sequence. © 2018 Storozhenko et al.; licensee Beilstein-Institut. License and terms: see end of document.