Astra Salvensis.
Transilvanian Association for the Literarure and Culture of Romanian People (ASTRA).
Vol. 6.
2018.
P. 753-766
Mn-mediated sequential three-component domino Knoevenagel/cyclization/Michael addition/oxidative cyclization reaction towards annulated imidazo[1,2-a]pyridines
The sequential three-component reaction between o-hydroxybenzaldehydes, N-(cyanomethyl)pyridinium salts and a nucleophile towards substituted chromenoimidazopyridines under oxidative conditions has been developed. The employment of Mn(OAc)3•2H2O or KMnO4 as stoichiometric oxidants allowed the use of a wide range of nucleophiles, such as nitromethane, (aza)indoles, pyrroles, phenols, pyrazole, indazole and diethyl malonate. The formation of the target compounds presumably proceeds through a domino Knoevenagel/cyclization/Michael addition/oxidative cyclization reaction sequence. © 2018 Storozhenko et al.; licensee Beilstein-Institut. License and terms: see end of document.
Authors
Storozhenko O.A.
1
,
Festa A.A.
1
,
Ndoutoume D.R.B.
1
,
Aksenov A.V.
2
,
Varlamov A.V.
1
,
Voskressensky L.G.
1
Publisher
Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
Language
English
Pages
3078-3087
Status
Published
Link
Volume
14
Year
2018
Organizations
- 1 Organic Chemistry Department, Peoples' Friendship University of Russia, RUDN University, Miklukho-Maklaya st. 6, Moscow, 117198, Russian Federation
- 2 Department of Chemistry, North Caucasus Federal University, Pushkin st. 1a, Stavropol, 355009, Russian Federation
Keywords
2-aminochromene; 2-iminochromene; Domino reaction; Imidazo[1,2-a]pyridine; Michael addition; Multicomponent reaction; Oxidation; Pyridine amination
Date of creation
04.02.2019
Date of change
04.02.2019
Share
Other records
Bioorganic and Medicinal Chemistry.
2018.