The Study of Modern Wound Coatings Cytotoxicity for the Oral Mucosa Donor Site

Soft tissue plastic surgery is a popular procedure within dental surgery. Often this type of operation is accompanied by the collection of a soft tissue autograft. The hard palate mucosa is the area from which the graft is most often collected1. The wound surface after graft collection should be covered to minimize pain. Medical glue is the material of choice for such purposes. Recently, medical tissue adhesives have been studied as a good alternative to conventional suture materials, although the following properties, among others, must be considered: good adhesive strength, reliable polymerization in humid environments, biocompatibility, stability, and good working time2, 3. With this in mind, cyanoacrylate adhesives appear to be a good option for medical applications, particularly in dentistry4. Cyanoacrylates come in several different forms depending on the length and complexity of their chains; these include methyl, ethyl, n-butyl, isoamyl, isohexyl, and octyl cyanoacrylates5, 6. The aim of this study was a comparative assessment of the cytotoxic properties and safety of using medical adhesives from different manufacturers on the donor area on the palate during soft tissue plastic surgery. Cyanoacrylate-based adhesives (cyanoacrylic acid derivative) have less cytotoxicity to the underlying tissues compared to feracrylate-based adhesives (aqueous solution of feracrylate 1%). A cyanoacrylic acid-based medical adhesive can optimize the use of wound coverings on the donor area on the palate in soft tissue plastic surgery by exerting relatively negligible cytotoxicity on the surrounding tissue. © (2024), (University of Dicle). All rights reserved.