The reasons behind rehabilitation of children with recurrent respiratory infections (RRI) being not efficient enough are the presence of coinfection, comorbid diseases, and difficulties in identifying the principal pathology. It has been demonstrated that young children with viral coinfections observed by the authors based on consulting and diagnosing department No. 1 Children's Regional Clinical Hospital of Krasnodar in 2017-2020 have clinical signs of the compromised immune system: high recurrence of ARVI, their association with latent or persistent herpes virus infection – HVI, with a secondary bacterial infection of the respiratory tract and ORL-organs, and resistance to conventional therapy. When studying the immune and interferon system, the authors noted irrelevant response of the inborn and adaptive mechanisms of anti-infective protection, defects of neutrophilic granulocytes (NG) functioning, and the deficiency of IFNα. A new 90 days program of integrated rehabilitation involving the long-term continuous local and prolonged intermittent systemic therapy with recombinant interferon α2b (rIFNα2b) combined with antioxidants (Viferon®) has been developed. As a result of the integrated rehabilitation conducted, the lower frequency and duration of RRI and the reduced activity of HVI have been registered, which was accompanied by normalization of the inborn and adaptive immunity indicators. The suggested tactics of prolonged local and systemic interferon therapy optimizes the treatment and demonstrates positive clinical-immunological and stable protective effects in immunocompromised young children having viral coinfections. © 2020, Advanced Scientific Research. All rights reserved.