Changing Phenotypes of 2 Subpopulations Neutrophilic Granulocytes-CD62L(+)CD63(+) and CD64(+)CD16(+)CD32(+)CD11b(+) in Neonatal Infections
The development of new diagnostic technologies allowed us to expand and deep our understanding of the role of neutrophilic granulocytes (NG) in immune homeostasis and to evaluate the dynamic interrelation between functional potential and phenotypic polarization NG cells in response to inducing signals of intra- and extracellular environment. Until now it is still not completely known how many NG phenotypes are available to realize contents of the granular apparatus, to produce active forms of oxygen, to carry out phagocytosis and cytotoxicity that differ in their properties. Lack of adequate response, hyperactivation or blockade of NG functions leads to the development of infection inflammatory diseases. Term infants with infection inflammatory processes was characterized by increasing of phenotypes CD62L+CD63 +NG, CD64+CD16+CD32+CD11b+NG with different density of the functionally important receptors in congenital pneumonia and neonatal sepsis, which allows assessing the severity of inflammatory process course and role of each of the identified subsets in immunopathogenic of these diseases.