The use of selective beta-adrenoblocker bisoprolol in patients with acute myocardial infarction and concomitant chronic obstructive bronchitis

Aim. To study effect of bisoprolol on characteristics of pulmonary ventilatory function in patients with acute myocardial infarction and chronic obstructive bronchitis. Material and methods. Standard spirometric indices were determined before and after 30 days of treatment with bisoprolol in 30 patients with acute myocardial infarction and concomitant chronic obstructive bronchitis (19 men and 11 women, mean age 60,4+/-2,2 years). Results. During treatment with bisoprolol most of the patients had no early postinfarction angina, progression of heart failure, or recurrences of myocardial infarction. In 2 patients the drug was stopped because of exacerbation of bronchitis during concomitant pneumonia. Before bisoprolol all patients had impaired tracheal and bronchial conductance. Vital capacity was within predicted limits while conductivity of large and medium-sized airways was 37,1 and 51,4% lower than predicted values, respectively. There were no signs of obstruction of small airways. After bisoprolol insignificant increase of vital capacity occurred (from 2,92+/-0,48 to 3,3+/-0,54 l). Other spirometric parameters did not change. No signs of further impairment of bronchial conductance were observed during treatment with bisoprolol.