Hypolipidemic effect and leskol tolerance in hypertensive patients with hypercholesterolemia: Results of multicenter trial

Hypertensive patients with hyperlipidemia are at high risk to develop coronary heart disease (CHD). Chemotherapeutic correction of hyperlipidemia seems most reliable modality to prevent CHD. Hypolipidemic effect and tolerance of leskol (fluvastatin) in dietotherapy-resistant hypercholesterolemia were studied in 74 patients with essential hypertension treated with hypotensive drugs. The patients were included in a multicenter trial. A 12-week course reduced total cholesterol level under 6.2 mmol/l in 59% of the patients, under 5.2 mmol/l in 29% of them. LDLP cholesterol lowered to 3.5% in 34% of the patients. Mean apo B diminished by 23%. There was a 27% decrease in the proportion of atherogenic fraction apo B to antiatherogenic fraction of transport proteins apo A-I. Leskol is well tolerated and effective against hypercholesterolemia, it is safe in relation to side effects and blood biochemistry.

Авторы
Aronov D.M.1 , Akhmedzhanov N.M.1 , Vartanova O.A.1 , Volchkova T.M.1 , Gratsiansky N.A.1 , Ivleva Ya.A. , Kobalava Zh.D. , Melkina O.E.1 , Moiseev V.S. 1 , Olferyev A.M.1 , Olbinskaya L.I.1 , Perova N.V.1 , Pyzh M.V.1
Редакторы
-
Издательство
-
Номер выпуска
1
Язык
Русский
Страницы
45-48
Статус
Опубликовано
Подразделение
-
DOI
-
Номер
-
Том
67
Год
1995
Организации
  • 1 Ross. Universitet Druzhby Narodov, Moskva, Russian Federation
Ключевые слова
antihypertensive agent; apolipoprotein b; fluindostatin; low density lipoprotein cholesterol; fluindostatin; hypocholesterolemic agent; indole derivative; lipid; monounsaturated fatty acid; article; cholesterol blood level; clinical trial; coronary artery disease; drug efficacy; drug tolerance; essential hypertension; human; hypercholesterolemia; major clinical study; multicenter study; adult; blood; female; hypercholesterolemia; hypertension; male; Russian Federation; time; Anticholesteremic Agents; Drug Tolerance; English Abstract; Fatty Acids, Monounsaturated; Female; Human; Hypercholesterolemia; Hypertension; Indoles; Lipids; Male; Middle Age; Moscow; Support, Non-U.S. Gov't; Time Factors
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/892/