Novel nitrogen containing steroid derivatives for prostate cancer treatment

This mini-review focuses on the investigation of novel nitrogen-containing steroid derivatives that are potentially applicable for prostate cancer treatment. It covers the literature of the last decade, highlighting the structure of new steroid compounds that exhibit significant activity in prostate cancer cells and possess pharmacological potency. New derivatives of known anti-prostate cancer agents: abiraterone and galeterone, new derivatives of androstane and pregnane modified with nitrogen-containing heterocycles, and some related steroid-derived compounds are discussed in the review. © 2021 Bentham Science Publishers.

Авторы
Latysheva A.S.1 , Zolottsev V.A. 1 , Pokrovsky V.S. 2, 3 , Khan I.I. 2, 3 , Misharin A.Yu.1
Издательство
Bentham Science Publishers B.V.
Номер выпуска
40
Язык
Английский
Страницы
8416-8432
Статус
Опубликовано
Том
28
Год
2021
Организации
  • 1 V.N. Orekhovich Institute of Biomedical Chemistry, 10, Pogodinskaya Street, Moscow, 119435, Russian Federation
  • 2 N.N. Blokhin National Medical Research Center of Oncology of Ministry of Health of Russian Federation, 24, Kashirskoye highway, Moscow, 115478, Russian Federation
  • 3 RUDN University, 6, Miklukho-Maklaya street, Moscow, 117198, Russian Federation
Ключевые слова
Abiraterone; Androgen deprivation therapy; Anti-prostate cancer agents; Galeterone; Novel nitrogen; Prostate cancer; Steroid CYP17A1 inhibitors
Дата создания
06.07.2022
Дата изменения
06.07.2022
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/84777/
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