Misdiagnosis of diabetic foot ulcer in patients with undiagnosed skin malignancies

A growing number of studies report dermal malignancies mimicking diabetic foot ulcers (DFUs). We reviewed clinical cases reporting malignant tumours misdiagnosed to be DFU aiming to identify factors contributing to misdiagnosis. We systematically searched in PubMed for clinical cases reporting on misdiagnosis of DFU in patients with cancer. A chi-square analysis was conducted to show the link between the incidence of initial DFU misdiagnosis and patient age, gender and wound duration. Lesions misdiagnosed to be DFU were subsequently diagnosed as melanoma (68% of the cases), Kaposi's sarcoma (14%), squamous cell carcinoma (11%), mantle cell lymphoma, and diffuse B-cell lymphoma (both by 4%). Older age (≥65 years) was associated with a significantly increased risk of malignancy masked as DFU (OR: 2.452; 95% CI: 1.132 to 5.312; P value =.019). The risk of such suspicion in older patients (age ≥ 65 years) was 145% higher than in younger patients (age < 65 years). Clinicians should maintain a high level of awareness towards potentially malignant foot lesions in elderly patients with diabetes (age ≥ 65). © 2021 The Authors. International Wound Journal published by Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd.

Lyundup A.V. 1 , Balyasin M.V. 1 , Maksimova N.V.2 , Kovina M.V. 1, 3 , Krasheninnikov M.E. 1 , Dyuzheva T.G.2 , Yakovenko S.A.3, 4 , Appolonova S.A.2 , Schiöth H.B.2, 5 , Klabukov I.D.6
John Wiley and Sons Inc
  • 1 Peoples' Friendship University of Russia, Moscow, Russian Federation
  • 2 Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
  • 3 AltraVita IVF Clinic, Moscow, Russian Federation
  • 4 Department of Biophysics, Faculty of Physics, Lomonosov's Moscow State University, Moscow, Russian Federation
  • 5 Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
  • 6 National Medical Research Radiological Center, Obninsk, Russian Federation
Ключевые слова
diabetic foot ulcer; malignancy; melanoma; misdiagnosis; skin cancer
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