Chemical Structure, Hypoglycemic Activity, and Mechanism of Action of Selenium Polysaccharides

Selenium polysaccharides (Se-polysaccharides) are one of important forms of organic Se, in which selenium (Se) and polysaccharides are joined by covalent bonds. In the present review, recent progress in chemical structure and hypoglycemic activity of Se-polysaccharides is summarized. In particular, the mechanism underlying hypoglycemic capacity of Se-polysaccharides is discussed, and the relationship between hypoglycemic activity and chemical structure is analyzed. Besides, strategies for further research into chemical structure and hypoglycemic activity of Se-polysaccharides are proposed. Hypoglycemic activity of Se-polysaccharides is closely related to their inhibitory effect on α-amylase and α-glucosidase, influence on insulin signal pathway especially IRS-PI3K-Akt signaling pathway, and protection capacity against oxidative stress. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Duan W.-X.1 , Yang X.-H.2 , Zhang H.-F.1, 3 , Feng J. 4 , Zhang M.-Y.1, 3
Humana Press Inc.
  • 1 Provincial Research Station of Se-Enriched Foods in Hanyin County of Shaanxi Province, International Joint Research Center of Shaanxi Province for Food and Health Sciences, National Engineering Laboratory for Resources Development of Endangered Crude Drugs in Northwest China, Shaanxi Normal University, Xi’an, 710062, China
  • 2 Health Science Center, Xi’an Jiaotong University, Xi’an, 710061, China
  • 3 Municipal Expert Workstation for Hua-Feng Zhang, Academician and Expert Workstation in Pu’er City of Yunnan Province, Pu’er, 665600, China
  • 4 Agrarian and Technological Institute, Peoples’ Friendship University of Russia, Moscow, 119991, Russian Federation
Ключевые слова
Chemical structure; Hypoglycemic activity; Mechanism of action; Se-polysaccharides; Structure–activity relationship
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