Experimental Study of the Efficacy of Sodium Deoxyribonucleate Used in Combination with Co-Transplantation of Mesenchymal and Hematopoietic Stem Cells after Exposure to ?-Radiation

We studied the possibility of using sodium deoxyribonucleate (Derinat) for improving the efficiency of co-transplantation of mesenchymal (MSC) and hematopoietic stem cells (HSC) to female F1(CBA×C57BL/6) mice with bone marrow aplasia caused by exposure to ?-radiation. It was found that immunomodulator Derinat enhanced the effect of co-transplantation, in particular, triple post-irradiation administration of Derinat accelerated hematopoiesis recovery judging from the parameters of peripheral blood, total cellularity of the bone marrow and spleen, and animal survival. Single or double administration of Derinat prior to irradiation was ineffective. The optimal result was obtained when the following scheme was applied: MSC?HSC with an interval of 48 h starting during the first hours after irradiation and triple administration of Derinat (in 10-15 min, 3 and 7 days after irradiation) in a dose of 3 mg/mouse. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.

Авторы
Pavlova L.N.1 , Zhavoronkov L.P.1 , Pavlov V.V.2 , Panfilova V.V.1 , Izmest’eva O.S.1 , Chibisova O.F.1 , Ivanov V.L.1 , Shegai P.V. 3 , Kaprin A.D. 3, 4
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
2
Язык
Английский
Страницы
236-244
Статус
Опубликовано
Том
172
Год
2021
Организации
  • 1 A. F. Tsyb Medical Radiological Research Center, Affiliated Branch of the National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Obninsk, Russian Federation
  • 2 Clinical Hospital No. 8, Federal Medical-Biological Agency of Russia, Obninsk, Russian Federation
  • 3 National Medical Research Centre of Radiology, Ministry of Health of the Russian Federation, Obninsk, Russian Federation
  • 4 Peoples’ Friendship University of Russia, Moscow, Russian Federation
Ключевые слова
co-transplantation; hemopoiesis; linear mice; sodium deoxyribonucleate; stem cells
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