Oleaginous microalgae are being used extensively worldwide for the development of integrated sustainable environment technologies. Microalgae can be used to remove environmental pollutants and simultaneous extraction of biofuels from the same culture. Microalgae have also evolved different intracellular and extracellular mechanisms to resist the toxic effects of different environmental pollutants that stimulate lipid accumulation. The advancements in microalgae omics with the use of recent tools like H1NMR spectroscopy, GC-MS, FTIR spectroscopy, ICP-MS, LC-MS can provide deep insights towards understanding the various underlying mechanisms to resist environmental stresses. They are a promising candidate towards Green Bioremediation and Biofuel production. © 2021 The Authors