CLOZAPINE AND CLOZAPINE-ETHANOL POISONING AS A CAUSE OF HISTOMORPHOLOGICAL CHANGES IN THE CEREBELLUM

Clozapine is an atypical neuroleptic with a narrow therapeutic index which is widely used in clinical practice. Due to its psychotropic effect the drug is often misused. Experimental studies were performed on 25 outbreed mail rats. The animals were divided into 5 groups (the controls and four experimental groups). The controls included 5 intact rats. The experimental groups 1 and 2 were treated with clozapine at a dose 150 mg/kg. The experimental groups 3 and 4 received clozapine at the same dose and ethanol (2 ml/kg 70% ethanol). Severe damage to the Purkinje cells of the cerebellum was confirmed by an increase in the number of neurons that register signs of both reversible and irreversible damage. Purkinje cell alteration has increased by 24 hours from the beginning of the experiment.

Авторы
Журнал
Издательство
EUROPAISCHE WISSENSCHAFTLICHE GESELLSCHAFT EV
Номер выпуска
4
Язык
Английский
Страницы
69-71
Статус
Опубликовано
Том
10
Год
2020
Организации
  • 1 Fed Res & Clin Ctr Intens Care Med & Rehabilitol, Moscow, Russia
  • 2 RUDN Univ, Peoples Friendship Univ Russia, Moscow, Russia
Ключевые слова
clozapine; ethanol; poisoning; cerebellum; histomorphological changes
Дата создания
20.04.2021
Дата изменения
20.04.2021
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/73205/
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