HISTOMORPHOLOGICAL ALTERATIONS IN THE LUNGS IN ACUTE COMBINED BACLOFEN AND ETHANOL POISONING

A generic Baclofen, also known under the brand name of Lioresal, is a derivative of gamma-aminobutyric acid. Due to its psychotropic effect it is often used as a drug of abuse and for criminal poisoning. An experimental study was carried out on 5 Wistar rats (versus 5 intact rats of the control group) exposed to combined Baclofen (at a dose of 85 mg/kg) and ethanol (7 ml/kg of 40% ethanol) poisoning. We have identified a complex of pathological changes in the lungs of the rats in the early period after the experiment. The outcomes included circulatory disorders of the pulmonary microvasculature (plethora of capillaries, venules), emphysema, atelectasis and dystelectasis, infiltration of white blood cells into intraalveolar septa and thickening of intraalveolar septa due to edema. To quantify the severity of histomorphological changes in the lungs a morphometric study is required.

Авторы
Romanova O. 1, 2 , Sundukov D. 1 , Golubev A. 1, 2 , Blagonravov M. 1 , Barinov E. 1, 3 , Churilov A.2 , Ershov A.2, 4
Журнал
Издательство
EUROPAISCHE WISSENSCHAFTLICHE GESELLSCHAFT EV
Номер выпуска
4
Язык
Английский
Страницы
66-68
Статус
Опубликовано
Том
10
Год
2020
Организации
  • 1 RUDN Univ, Peoples Friendship Univ Russia, Moscow, Russia
  • 2 Fed Res & Clin Ctr Intens Care Med & Rehabilitol, Moscow, Russia
  • 3 Yevdokimov Moscow State Univ Med & Dent, Moscow, Russia
  • 4 First Med Sechenov Univ, Moscow, Russia
Ключевые слова
Baclofen; ethanol; poisoning; lungs; histomorphological changes
Дата создания
20.04.2021
Дата изменения
29.06.2022
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/73204/
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