Antihypertensive therapy: Controlling the processes of replicative cell senescence

The review includes data over the past 20 years on the mechanisms of the influence of hypertension and related interdependent conditions, such as insulin resistance, chronic inflammation and oxidative stress on the vascular ageing. The review also discusses modern concepts of the interaction of biological and vascular aging, as well as possible ways of their reversal. The central indicators of biological aging in this review are telomere length and telomerase activity. The article discusses antihypertensive therapy as a possible way to slow down both vascular and biological aging, and describes the results of modern studies on the effect of various antihypertensives, including angiotensin-converting enzyme inhibitors, sartans and others, on the telomeres. © 2020, Silicea-Poligraf. All rights reserved.

Авторы
Dudinskaya E.N.1 , Machekhina L.V.1 , Eruslanova K.A.1 , Dogotar O.A. 2 , Ryltseva L.P. 2 , Lyzlova N.Y. 2 , Shchepin N.A. 2 , Kotovskaya Y.V. 1 , Tkacheva O.N. 1
Издательство
Silicea-Poligraf
Номер выпуска
s3
Язык
Русский
Страницы
7-15
Статус
Опубликовано
Номер
3974
Том
25
Год
2020
Организации
  • 1 Pirogov Russian National Research Medical University, Russian Clinical and Research Center of Gerontology, Moscow, Russian Federation
  • 2 Peoples’ Friendship University of Russia, Moscow, Russian Federation
Ключевые слова
Aging; Hypertension; Insulin resistance; Oxidative stress; Telomerase; Telomeres
Дата создания
20.04.2021
Дата изменения
20.04.2021
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/72879/
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