Sustainable Development of Mountain Territories.
North Caucasian Institute of Mining and Metallurgy, State Technological University.
Vol. 12.
2020.
P. 349-356
Antihypertensive therapy: Controlling the processes of replicative cell senescence
The review includes data over the past 20 years on the mechanisms of the influence of hypertension and related interdependent conditions, such as insulin resistance, chronic inflammation and oxidative stress on the vascular ageing. The review also discusses modern concepts of the interaction of biological and vascular aging, as well as possible ways of their reversal. The central indicators of biological aging in this review are telomere length and telomerase activity. The article discusses antihypertensive therapy as a possible way to slow down both vascular and biological aging, and describes the results of modern studies on the effect of various antihypertensives, including angiotensin-converting enzyme inhibitors, sartans and others, on the telomeres. © 2020, Silicea-Poligraf. All rights reserved.
Authors
Dudinskaya E.N.1
,
Machekhina L.V.1
,
Eruslanova K.A.1
,
Dogotar O.A.
2
,
Ryltseva L.P.
2
,
Lyzlova N.Y.
2
,
Shchepin N.A.
2
,
Kotovskaya Y.V.
1
,
Tkacheva O.N.
1
Journal
Publisher
Silicea-Poligraf
Number of issue
s3
Language
Russian
Pages
7-15
Status
Published
Link
Number
3974
Volume
25
Year
2020
Organizations
- 1 Pirogov Russian National Research Medical University, Russian Clinical and Research Center of Gerontology, Moscow, Russian Federation
- 2 Peoples’ Friendship University of Russia, Moscow, Russian Federation
Keywords
Aging; Hypertension; Insulin resistance; Oxidative stress; Telomerase; Telomeres
Date of creation
20.04.2021
Date of change
20.04.2021
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Вопросы литературы.
Автономная некоммерческая организация Редакция журнала критики и литературоведения Вопросы литературы.
Vol. 2020.
2020.
P. 150-165