Structure, nitric oxide (NO) generation and antitumor activity of binuclear tetranitrosyl iron complex with 4-aminothiophenolyl as nitrosyl ferredoxins mimic

Single-crystal XRD structure of binuclear tetranitrosyliron complex [Fe2(SR)2(NO)4] (1), R = 4-aminothiophenyl, has been described. The properties of 1 were studied by IR, Mössbauer, mass spectroscopy, and amperometry. Complex 1 was shown to form long-living nitrosyl intermediates in solution, which underlies its prolonged NO donor activity. In HeLa cells, 1 caused accumulation of NF-κB p50 but decreased the levels of NF-κB p65 in the nucleus, which led to inhibition of NF-κB dependent genes. The complex also induced increase of p53 protein levels and p21 gene activity, which led to the apoptotic cell death after G2/M cell cycle phase. © 2021 Informa UK Limited, trading as Taylor & Francis Group.

Sanina N.A. 1, 2, 3 , Kozub G.I.1 , Kondrat’eva T.A.1 , Stupina T.S.1, 3 , Balakina A.A.1, 3 , Terent’ev A.A. 1, 2, 3 , Sulimenkov I.V.4 , Ovanesyan N.S.1 , Dorovatovskii P.V. 5 , Khrustalev V.N. 5, 6 , Aldoshin S.M. 1, 2
Taylor and Francis Ltd.
  • 1 Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Russian Federation
  • 2 Faculty of Fundamental Physicochemical Engineering, Moscow State University, Moscow, Russian Federation
  • 3 Scientific and Educational Center “Medical Chemistry”, Moscow State Regional University, Mytishchi, Moscow Region, Russian Federation
  • 4 Chernogolovka Branch of the N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of SciencesChernogolovkа, Russian Federation
  • 5 National Research Center “Kurchatov Institute”, Moscow, Russian Federation
  • 6 Peoples’ Friendship University of Russia (RUDN University), Moscow, Russian Federation
Ключевые слова
4-aminothiophenyl; apoptosis; BIRC2; BIRC3; ICAM1; IL6; IL8; IR spectroscopy; mass spectrometry; Mössbauer spectroscopy; NF-κB; Nitrosyl iron complexes; p21; p50; p53; p65; X-ray diffraction
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