Pharmacological regulation with antioxidants of hepatocyte cytolysis in acute D-galactosamine-induced intoxication

A rat model of D-galactosamine-induced (0.3 g/kg) liver damage is used to study antioxidant and membrane-stabilizing activity of sodium selenite, vitamin E, and their combination (administered per os, daily, for 3 days before intoxication). It is shown that sodium selenite is 300-fold more effective than vitamin E, while their combination exhibits synergism and potentiation of the antioxidant and membrane-stabilizing activities, underlying inhibition of hepatocyte cytolysis. ©1998 Plenum Publishing Corporation.

Редакторы
-
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
4
Язык
Английский
Страницы
367-369
Статус
Опубликовано
Подразделение
-
Номер
-
Том
125
Год
1998
Организации
  • 1 Laboratory of Pharmacology, Institute of General and Clinical Pathology, University of Peoples' Friendship, Moscow, Russian Federation
Ключевые слова
Cytolysis; D-galactosanime hydrochloride; Liver; Sodium selenite; Vitamin E
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/664/