Electrochemical characterization of a novel nimesulide anti-inflammatory drug analog: LQFM-091

Nimesulide is an anti-inflammatory drug (NSAID) whose preferential selectivity for cyclooxygenase-2 (COX-2) leads to fewer adverse effects. Nimesulide acts on a single metabolic pathway of the arachidonic acid cascade. Recent studies show that multi-target NSAID is an important strategy for obtaining drugs fewer adverse effects. LQFM-091 has been proposed as a molecular hybridization from nimesulide and BF-389, with the aim to inhibit two enzymes involved in arachidonic acid metabolic cascade. The aim this work was the electrochemical characterization of LQFM-091. The electrochemical analyzes were conclusive to prove that the electroactive groups are unhindered and were important in this drug action mechanism. © 2018

Авторы
De Siqueira Leite K.C. , Garcia L.F.1 , Sanz G.2 , Colmati F.2 , De Souza A.R. , Da Costa Batista D. , Menegatti R.1 , De Souza Gil E. , Luque R. 3, 4
Редакторы
-
Издательство
-
Номер выпуска
-
Язык
Английский
Страницы
92-96
Статус
Опубликовано
Подразделение
-
Номер
-
Том
818
Год
2018
Организации
  • 1 Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO 74605–220, Brazil
  • 2 Instituto de Química, Universidade Federal de Goiás, Goiânia, GO 74690-970, Brazil
  • 3 Departamento de Quimica Organica, Universidad de Cordoba, Campus de Rabanales, Edificio Marie Curie, Ctra Nnal IV-A, Km. 396, Cordoba, E14014, Spain
  • 4 Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya street, Moscow, 117198, Russian Federation
Ключевые слова
Butylhydroxytoluene; Electroanalysis; Electrochemical characterization; Nimesulide; Novel drugs
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/6627/