Neuroprotective effect of the carnosine – α-lipoic acid nanomicellar complex in a model of early-stage Parkinson's disease

In a model of early-stage Parkinson's disease induced by a single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to Wistar rats, a neuroprotective effect of a new derivative of carnosine and α-lipoic acid (C/LA nanomicellar complex) was demonstrated. Acute intraperitoneal administration of carnosine, α-lipoic acid and C/LA complex following MPTP administration normalized the total antioxidant activity in the brain tissue. Of all the compounds tested only C/LA complex normalized the metabolism of dopamine (DA) and serotonin (5-HT), while its components did not show similar effects when used separately. C/LA complex effectively restored the level of DA metabolites: the level of DOPAC was increased by 24.7 ± 5.6% compared to the animals that had received MPTP only, and the level of HVA was restored to the values observed in the intact animals. Integral metabolic indices of DA (DOPAC/DA and HVA/DA ratios) and 5-HT turnover (5-HIAA/5-HT ratio) in the striatum tended to increase in case of C/LA complex administration. © 2018 Elsevier Inc.

Авторы
Kulikova O.I. 1, 3 , Berezhnoy D.S.1, 2 , Stvolinsky S.L.1 , Lopachev A.V.1 , Orlova V.S. 3 , Fedorova T.N.1
Издательство
Academic Press Inc.
Язык
Английский
Страницы
254-259
Статус
Опубликовано
Том
95
Год
2018
Организации
  • 1 Laboratory of Clinical and Experimental Neurochemistry, Research Center of Neurology, Moscow, 125367, Russian Federation
  • 2 Faculty of Biology, Moscow State University, Moscow, 119234, Russian Federation
  • 3 Faculty of Ecology, Peoples' Friendship University of Russia, Moscow, 117198, Russian Federation
Ключевые слова
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Carnosine; Catecholamines; Lipid peroxidation; Nanomicellar complex of carnosine and α-lipoic acid; Neuroprotection; Parkinson's disease; Rat; α-lipoic acid
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/6626/
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