Transformations of (γ-piperidono)dibenzoaza-14-crown-4 ethers

The transformations of dibenzo[(γ-piperidono]aza-14-crown-4 ethers were implemented with Li-organic compounds and sodium borohydride under reduction condition. The structures of new compounds were confirmed by1H NMR, IR, MS analysis. X-Ray single-crystal structure study has exactly determined the structure of the representative compound 2g. According to the PASS program, these obtained new azacrown ethers containing γ-piperidol fragment are interested to develop new biologically active agents such as a CYP2H substrate (60–95 %), membrane permeability inhibitor (60–74 %) and spasmolytic agent (60–92 %). © ISUCT Publishing.