Proceedings of Science. Vol. 353. 2019.
Transformations of (γ-piperidono)dibenzoaza-14-crown-4 ethers
The transformations of dibenzo[(γ-piperidono]aza-14-crown-4 ethers were implemented with Li-organic compounds and sodium borohydride under reduction condition. The structures of new compounds were confirmed by1H NMR, IR, MS analysis. X-Ray single-crystal structure study has exactly determined the structure of the representative compound 2g. According to the PASS program, these obtained new azacrown ethers containing γ-piperidol fragment are interested to develop new biologically active agents such as a CYP2H substrate (60–95 %), membrane permeability inhibitor (60–74 %) and spasmolytic agent (60–92 %). © ISUCT Publishing.
Authors
Hieu T.H. 1, 5 , Komarova A.I. 2 , Levov A.N. 2 , Soldatenkov A.T. 2 , Polyakova E.I. 2 , Tuyen N.V. 1, 4 , Anh D.T.T. 1, 4 , Kulakova A.N. 2 , Khrustalev V.N. 2 , Anh L.T. 3
Journal
Issue number
4
Language
English
Pages
409-414
State
Published
Link
Volume
12
Year
2019
Organizations
- 1 Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Viet Nam
- 2 Department of Inorganic Chemistry, Peoples’ Friendship, University of Russia, RUDN University), Moscow, 117198, Russian Federation
- 3 Faculty of Chemistry, VNU University of Science, Vietnam National University, Hanoi, Viet Nam
- 4 Graduate University of Science and Technology, VAST, Hanoi, Viet Nam
- 5 Saigon Pharmaceutical Science-Technology Centre, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, 70000, Viet Nam
Keywords
Azacrown ether; Li-organic compound; Single-crystal X-ray structure; γ-piperidol
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