The use of autologous mesenchymal stem cells for endometrial repair in patients with lower fertility

Objective: Evaluation of the effectiveness of mesenchymal stem cells (MSC) in patients with lower fertility associated with Asherman’s syndrome and an extremely thin endometrium. Patients and methods: A pilot study was conducted with participation of 11 women aged 25-43 years. The endometrium was evaluated by dynamic transvaginal ultrasound (US) with Doppler imaging, outpatient hysteroscopy on the 7-9th day of the menstrual cycle (m.c.). Autologous MSC were collected from adipose tissue or menstrual blood. Intravenous and intrauterine injection of autologous MSC was performed on the 3-4th m.c. The effect of therapy was assessed by the occurrence of pregnancy and also by echographic characteristics of the endometrium. Results: The use of MSC was attended by a significant (р < 0.003) increase of endometrial thickness according to US findings and a decrease of the resistivity index of basal arteries in all patients, restoration of normal endometrial thickness and structure in 8 patients. Control outpatient hysteroscopy did not reveal any recurrence of intrauterine synechiae. Clinical pregnancy was recorded in 6 cases. Conclusion: The use of autologous MSC is a promising method of overcoming infertility in patients with Asherman’s syndrome and an extremely thin endometrium not responding to standard therapy. © 2019, Dynasty Publishing House. All rights reserved.

Kuznetsova I.V. 1 , Zemlina N.S.1 , Musina R.A.2 , Musina K.S.2 , Bekchanova E.S.2 , Dzhibladze T.A.2 , Kovalenko M.A.1 , Tapilskaya N.I.3 , Radzinskiy V.E. 4
Dynasty Publishing House
Номер выпуска
  • 1 Department of obstetrics and gynaecology No 1, Faculty of medicine, I.M.Sechenov First Moscow State Medical University (Sechenov University), 2/1 Elanskii str, Moscow, 119435, Russian Federation
  • 2 Multi-Specialty Medical Holding CM Clinic, 4/2 Yaroslavskaya str, Moscow, 129164, Russian Federation
  • 3 Department of ART, D.O.Ott Research Institute of Obstetrics, Gynaecology and Reproduction, 3 Mendeleevskaya line, St.Petersburg, 199034, Russian Federation
  • 4 Department of obstetrics and gynaecology, People’s Friendship University of Russia (RUDN University), 21/3 Miklukho-Maklai str, Moscow, 117198, Russian Federation
Ключевые слова
Assisted reproductive technologies; Chronic endometritis; Habitual abortion; Infertility; Intrauterine synaechiae; Ivf failures; Mesenchymal stem cells
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