Laboratory Diagnostics of Ovarian Cancer among the Elderly Based on the Parameters of Immunoglobulins and Phagocytic Activity of Blood

Abstract: New diagnostic methods are being sought for ovarian cancer due to its higher prevalence, which is the result of an increase in the share of elderly women. The purpose of this study was to analyze the content and sensitivity of immunoglobulins and the phagocytic activity of peripheral blood in order to improve the diagnostics of ovarian cancer among elderly women. The phagocytic activity and the immunoglobulin level in the peripheral blood were assessed with immunological and spectrophotometric methods in 78 patients with ovarian cancer aged 65–70 years. The control group comprised 42 women of the same age with no ovarian cancer. The primary importance of circulating immune complexes and the indices of neutrophil activity and the inhibition of phagocyte migration was established for laboratory diagnostics of ovarian cancer among elderly people. The use of highly informative parameters of systemic immunity may enhance the diagnostics of ovarian cancer in the elderly. © 2020, Pleiades Publishing, Ltd.

Авторы
Agarkov N.M.1 , Kicha D.I. 2 , Harchenko V.V. 3 , Koptev D.S.1 , Korovin E.N.4 , Blinkov Y.Y.3 , Budnik I.V.5
Издательство
Maik Nauka Publishing / Springer SBM
Номер выпуска
1
Язык
Английский
Страницы
57-61
Статус
Опубликовано
Том
10
Год
2020
Организации
  • 1 Southwest State University, Kursk, 305040, Russian Federation
  • 2 Peoples’ Friendship University of Russia, Moscow, 117198, Russian Federation
  • 3 Kursk State Medical University, Kursk, 305041, Russian Federation
  • 4 Voronezh State Technical University, Voronezh, 394026, Russian Federation
  • 5 Pirogov First City Hospital, Moscow, 119049, Russian Federation
Ключевые слова
ovarian cancer in the elderly; radial immunodiffusion method; spectrophotometric method; systemic immunity
Дата создания
02.11.2020
Дата изменения
02.11.2020
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/65599/