Clustering of Thrombin Generation Test Data Using a Reduced Mathematical Model of Blood Coagulation

Correct interpretation of the data from integral laboratory tests, including Thrombin Generation Test (TGT), requires biochemistry-based mathematical models of blood coagulation. The purpose of this study is to describe the experimental TGT data from healthy donors and hemophilia A (HA) and B (HB) patients. We derive a simplified ODE model and apply it to analyze the TGT data from healthy donors and HA/HB patients with in vitro added tissue factor pathway inhibitor (TFPI) antibody. This model allows the characterization of hemophilia patients in the space of three most important model parameters. The proposed approach may provide a new quantitative tool for the analysis of experimental TGT. Also, it gives a reduced model of coagulation verified against clinical data to be used in future theoretical large-scale modeling of thrombosis in flow. © 2019, Springer Nature B.V.

Ratto N.1 , Tokarev A. 3 , Chelle P.4, 5 , Tardy-Poncet B.5, 6, 7 , Volpert V. 1, 3, 2
NLM (Medline)
  • 1 Institute Camille Jordan, UMR 5208 CNRS, University Lyon 1, Villeurbanne, 69622, France
  • 2 Institute Camille Jordan, INRIA, Université de Lyon, Université Lyon 1, Villeurbanne, 69200, France
  • 3 Peoples’ Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
  • 4 Center for Health Engineering, UMR 5307, Ecole Nationale Supérieure des Mines de Saint-Etienne, Saint-Etienne, 42023, France
  • 5 Unite Inserm Sainbiose U1059, Université Jean Monnet, Saint-Etienne, 42023, France
  • 6 Inserm CIC1408, CHU de Saint-Etienne, Saint-Etienne, 42023, France
  • 7 CRC Hémophilie CHU St Etienne, Saint-Etienne, 42023, France
Ключевые слова
Hemophilia patients; Mathematical simulation; Model reduction; Thrombin generation test
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