Effect of Zn Supplementation on Trace Element Status in Rats with Diet-Induced Non-alcoholic Fatty Liver Disease

Abstract: The present study aimed to assess the effect of Zn supplementation on trace element levels in the liver, serum, and hair of rats with dietary-induced non-alcoholic fatty liver disease (NAFLD). A total of 26 3-month-old female Wistar rats were divided into four groups: control, NAFLD, Zn-supplemented (227 mg/L zinc as Zn sulfate Zn(SO)4 dissolved in a drinking water), and NAFLD-Zn-supplemented. NAFLD was verified by histological assessment of liver samples. The serum was examined for routine biochemical parameters. Trace elements content was assessed using inductively coupled plasma mass spectrometry (ICP-MS). Zn treatment resulted in an improvement in liver weight and morphology. Dietary supplementation with Zn prevented NAFLD-induced decrease liver Co. The tendency to increase liver Fe in the Zn-treated group was observed. Zn treatment decreased hepatic Al and serum V levels. However, Zn administration did not affect NAFLD-induced I, Mn, and Se depletion in the liver. Hair Zn levels raised in Zn-supplemented groups. Conclusively, the results of the study indicate that Zn supplementation could have a beneficial effect in modulation of the altered trace element status and liver morphology. Highlights: •Zn treatment improved liver weight and morphology in rats with NAFLD. •Zn supplementation decreased liver Al in NAFLD. •Treatment by Zn prevented depletion of liver Co. •Zn decreased serum V and increased hair Zn levels. •No effect of Zn on NAFLD-induced hepatic I, Mn and Se depletion was observed. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

Gatiatulina E.R. 1 , Sheina E.A. 2 , Nemereshina O.N. 3 , Popova E.V. 4 , Polyakova V.S. 3 , Agletdinov E.F.5 , Sinitskii A.I.6 , Skalny A.V. 2, 7, 8 , Nikonorov A.A. 9 , Tinkov A.A. 2, 7, 8
Humana Press Inc.
  • 1 All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Grina St., 7, Moscow, 117216, Russian Federation
  • 2 Peoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya St., 6, Moscow, 105064, Russian Federation
  • 3 Orenburg State Medical University, Sovetskaya St., 6, Orenburg, 460000, Russian Federation
  • 4 St. Joseph College of Health and Allied Sciences, St Joseph University in Tanzania, Dar es Salaam, 11007, Tanzania
  • 5 VECTOR-BEST, Po Box 492, Novosibirsk, 630117, Russian Federation
  • 6 South Ural State Medical University, Vorovskogo St., 64, Chelyabinsk, 454092, Russian Federation
  • 7 Yaroslavl State University, Sovetskaya St., 14, Yaroslavl, 150000, Russian Federation
  • 8 IM Sechenov First Moscow State Medical University, Trubetskaya St., 8-2, Moscow, 119991, Russian Federation
  • 9 State Research Center of Dermatovenerology and Cosmetology, Korolenko St., 3-6, Moscow, 107076, Russian Federation
Ключевые слова
Dietary intervention; Fatty liver; Metabolic study; Obesity; Zinc
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