Scientific papers and patents on substances with unproven effects. Part 2

Several examples are discussed in this review, where substances without proven effects were proposed for practical use within the scope of evidence-based medicines. The following is discussed here: generalizations of the hormesis concept and its use in support of homeopathy; phytoestrogens and soy products potentially having feminizing effects; glycosaminoglycans for the treatment of osteoarthritis and possibilities of their replacement by diet modifications; flavonoids recommended for the treatment of chronic venous insufficiency and varicose veins; acetylcysteine as a mucolytic agent and its questionable efficiency especially by an oral intake; stem cells and cell therapies. In conclusion, placebo therapies can be beneficial and ethically justifiable but it is not a sufficient reason to publish biased information. Importantly, placebo must be devoid of adverse effects, otherwise, it is named pseudo-placebo. Therapeutic methods with unproven effects should be tested in high-quality research shielded from the funding bias. Some issues discussed in this review are not entirely clear, and the arguments provided here can initiate a constructive discussion. © 2019 Bentham Science Publishers.

Авторы
Номер выпуска
3
Язык
Английский
Страницы
160-173
Статус
Опубликовано
Том
13
Год
2019
Организации
  • 1 Peoples’ Friendship, University of Russia, Clementovski per 6-82, Moscow, 115184, Russian Federation
Ключевые слова
Acetylcysteine; Hormesis; Nutrition; Osteoarthritis; Phytoestrogens; Placebo; Soy
Дата создания
10.02.2020
Дата изменения
10.02.2020
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/56345/