Gastroesophageal reflux disease in children with recurrent and chronic respiratory diseases: Frequency and information content of various diagnostic methods

Gastroesophageal reflux disease (GERD) has bronchopulmonary manifestations, often associated with recurrent and chronic respiratory diseases (RaCRD). Objective of the research: To determine the frequency of GERD in children with RaCRD and to assess the information content of various diagnostic methods. Materials and methods: Using the GERD-Q questionnaire and considering GERD equivalent symptoms, results of esophageal fluoroscopy with contrasting, esophagogastroduodenoscopy (EGDS), daily pH-metry, daily intra-esophageal combined impedance-pH-metry (CIM), 125 children aged 1 month to 17 years with RaCRD were examined. Results: In children with RaCRD the frequency of gastroesophageal reflux detected with maximum frequency (93%) using CIM was 90,4%, while 49,6% of patients did not have esophageal clinical manifestations of GERD. Among children without esophageal manifestations of GERD, reflux was confirmed by instrumental methods in 80,7% of patients. The leading type of reflux in children with RaCRD is sub-acid reflux, which is more common in children without esophageal manifestations of GERD. The prognostic significance of a positive result of esophagus fluoroscopy, endoscopy, and pH-metry is quite high (93,8–100%), but the prognostic significance of a negative result is very low (14,3–20%). Conclusion: GERD screening is possible in children with RaCRD, regardless of the clinical manifestations of GERD; for the diagnosis of GERD in these children CIM is recommended. © 2019, Pediatria Ltd. All right reserved.

Nguyen B.V. 1 , Ovsyannikov D. 2 , Ayrapetyan M.I.2, 3 , Gitinov S. 1 , Zhestkova M.A. 1 , Kovalenko I.V. 2 , Kurenkov I.V. 2 , Kurkin A.P.2 , Manukyan S.R.2 , Petryaykina E.E. 1, 2 , Skvortsova T.A.2 , Sokolov Y.2, 4 , Topilin O.G. 2 , Frolov P.A. 2 , Ho T.L. 1
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  • 1 Peoples’ Friendship University of Russia, Russian Federation
  • 2 Morozov Children’s City Clinical Hospital, Russian Federation
  • 3 I.M. Sechenov First Moscow State Medical University, Russian Federation
  • 4 Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
Ключевые слова
Children; Chronic respiratory diseases; Diagnosis; Gastroesophageal reflux disease; Recurrent respiratory diseases
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