Peptides Selected Using Phage Library Variants, Effectively Inhibit Trypanosoma cruzi Infection

Four peptide sequences characterized by high content of hydrophobic, charged, and polar amino acids were obtained from 23 clones of M13 phage. Peptides P2 and P4 exhibited highest binding affinity for immobilized trypomastigotes. The inhibitory effects of peptides seemed to be due to blockade of certain epitopes on T. cruzi surface proteins responsible for interactions with the respective receptors of host cells. © 2017, Springer Science+Business Media, LLC.

Авторы
Kleshchenko Y.E.1 , Zhigunova A.V. 1 , Dalin M.V. 1 , Melnikov V.2
Редакторы
-
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
3
Язык
Английский
Страницы
361-364
Статус
Опубликовано
Подразделение
-
Номер
-
Том
163
Год
2017
Организации
  • 1 Department of Microbiology and Virology, Medical Institute, Peopleэs Friendship University of Russia, Moscow, Russian Federation
  • 2 Laboratory of Molecular Biology, School of Medicine, University of Colima, Colima, Mexico
Ключевые слова
anti-infectious activity; peptides; Trypanosoma cruzi
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/5457/