Synthesis of 2-(chloro(methoxy, morpholino)methyl)-hexahydropyrimidothieno[3,2-c]azocines and tetrahydrospiro[pyrido[4,5']thieno[2,3-d]pyrimidines]

2-(Chloromethyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-ones reacted with acetylenedicarboxylate ester, methyl propiolate or acetylacetylene, forming mixtures of 2-(chloromethyl)-5,6,7,10-tetrahydropyrimido[5',4':4,5]thieno[3,2-d]azocin-4(3H)-ones and 2'-chloromethyl-6'-methylidene-2,3-dihydro-1H-spiro[pyrido[4,5']thieno[2,3-d]pyrimidin]-4'(3'H)-ones in various ratios. Analogous products were also obtained in the reaction of 2-(methoxymethyl) derivative with methyl propiolate, while using 2-[(morpholin-4-yl)-methyl] derivative in a similar reaction led to the formation of a more complex product mixture. © 2015 Springer Science+Business Media New York.

Редакторы
-
Издательство
Латвийский институт органического синтеза Латвийской академии наук / Springer New York Consultants Bureau
Номер выпуска
1
Язык
Английский
Страницы
17-25
Статус
Опубликовано
Подразделение
-
Номер
-
Том
51
Год
2015
Организации
  • 1 Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, 117198, Russian Federation
  • 2 University of Douala, Faculty of Science, Department of Chemistry, PO Box 2415A, Douala, Cameroon
  • 3 A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilova St., Moscow, 119991, Russian Federation
Ключевые слова
acetylacetylene; dimethyl acetylenedicarboxylate; domino reactions; methyl propiolate; pyridothienopyrimidines; pyrimidothieno[3,2-d]-azocines; recyclization; spiro[pyridine[4,5']thieno[2,3-d]pyrimidines]
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/4743/