N-acylation and N-alkylation of bis(benzo)aza-14-crown-4 ethers. Novel hybrid compound - bis(furanyl)triazinethiolazacrown ether

Macroheterocycles containing aza-14-crown-4 ether subunit were synthesized by one-step domino reaction. They are interesting objects for study of physicochemical properties and types of transformation. The N-acylated and N-alkylated aza-14-crown-4 ethers were obtained in good yields. The new hybrid compound - bis(furanyl)triazinethiolazacrown ether - was formed by S-alkylation of N-chloroacyl derivative (3). According to the PASS program, these substances can be inhibitors of the permeability of cell membrane and act also as a CYP2H substrate. © ISUCT Publishing.

Авторы
Hieu T.H. 1 , Komarova A.I. 2 , Levov A.N. 2 , Soldatenkov A.T. 2 , Polyakova E.I. 2 , Nguyen T.V.1, 4 , Anh D.T.T.1, 4 , Nguyen D.T.3 , Van T.T.T.3 , Anh L.T. 3
Редакторы
-
Журнал
Издательство
-
Номер выпуска
4
Язык
Английский
Страницы
438-441
Статус
Опубликовано
Подразделение
-
Номер
-
Том
11
Год
2018
Организации
  • 1 Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, 100000, Viet Nam
  • 2 Department of Chemistry, Peoples’ Friendship University of Russia, Moscow, 117198, Russian Federation
  • 3 Faculty of Chemistry, VNU University of Science, Hanoi, 100000, Viet Nam
  • 4 Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, 100000, Viet Nam
Ключевые слова
Acylation; Azacrown ether; Hybrid compound; Multicomponent condensation reaction; S-alkylation
Дата создания
19.07.2019
Дата изменения
19.07.2019
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/38335/