Molecular mechanisms of metabolic adaptation in liver to patological changes at toxic hepatitis

Possible molecular mechanisms underlying changes in catalytical properties of alcohol dehydrogenase (ADH) and lactate dehydrogenase (LDH) were studied at toxic hepatitis. The development of toxic hepatitis is accomanied by significant changes in the activity of ADH and LDH assayed in subcellular fractions and kinetic characteristics of these enzymes.This can result in an increase cellular level of acetylaldehyde and lactate which promotes the development of liver cirrosis.

Авторы
Zimin Yu.V.1 , Syatkin S.P. 2 , Berezov T.T. 2
Редакторы
-
Издательство
-
Номер выпуска
3
Язык
Русский
Страницы
351-352
Статус
Опубликовано
Подразделение
-
DOI
-
Номер
-
Том
47
Год
2001
Организации
  • 1 Molecular Pathology Group, Res. Inst. Traumatology Orthopedics, Verkhne - Volzhskaya nab.18, Nizhniy Novgorod 603155, Russian Federation
  • 2 Department of Biochemistry, Schooll of Medicine, Russ. Peoples' Friendship University, Mikluho-Maklay St. 8, Moscow 117198, Russian Federation
Ключевые слова
Alcohol dehydrogrenase; Hepatitis; Lactate dehydrogenase
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/358/