Molecular mechanisms of metabolic adaptation in liver to patological changes at toxic hepatitis

Possible molecular mechanisms underlying changes in catalytical properties of alcohol dehydrogenase (ADH) and lactate dehydrogenase (LDH) were studied at toxic hepatitis. The development of toxic hepatitis is accomanied by significant changes in the activity of ADH and LDH assayed in subcellular fractions and kinetic characteristics of these enzymes.This can result in an increase cellular level of acetylaldehyde and lactate which promotes the development of liver cirrosis.