Alcohol dehydrogenase ADH2-1 and ADH2-2 allelic isoforms in the Russian population correlate with type of alcoholic disease

The frequency ADH2-2 allele in the Moscow urban population and a correlation between the ADH2-2 allele, alcoholic dependence without cirrhosis, symptomatic alcoholic cirrhosis and status on hepatitis B and C infection have been studied. One hundred and twenty-three inhabitants of Moscow (50 healthy donors, 36 patients with alcoholic cirrhosis (subdivided into infected and uninfected by HBV and/or HCV) and 37 patients with alcoholic dependence) of a similar age/sex and drinking pattern have been analysed. The frequency of 41% for ADH2-2 allele is characteristic for an urban Moscow population. This value is intermediate between that found for Asian peoples and for Central and Western Europe. There is a negative correlation between the ADH2-2 allele and alcohol misuse (both alcoholic dependence and alcoholic cirrhosis). This correlation is expressed more in alcoholic dependence. In spite of the possession of the ADH2-2 allele (or genotype ADH2-1/2), alcohol misuse increases the risk of cirrhosis. At the same time, positive status for active hepatitis B, C or combined infection B + C (replication markers HBV-DNA or HCV-RNA) increases the risk for symptomatic alcoholic cirrhosis in alcohol abusing patients, independently of ADH2 genotype.

Авторы
Ogurtsov P.P. 1, 2, 4 , Garmash I.V. 1 , Miandina G.I. 1 , Guschin A.E.3 , Itkes A.V. 1 , Moiseev V.S. 1
Редакторы
-
Журнал
Издательство
-
Номер выпуска
4
Язык
Английский
Страницы
377-383
Статус
Опубликовано
Подразделение
-
Номер
-
Том
6
Год
2001
Организации
  • 1 Peoples Friendship University of Russia, School of Medicine, Moscow, Russian Federation
  • 2 Research Institute of Addictions, Department of Toxicology, Moscow, Russian Federation
  • 3 Central Research Institute on Epidemiology, Moscow, Russian Federation
  • 4 Department of Toxicology, Research Institute on Addictions, Kulikovskaya ul. 3-51, 113 628 Moscow, Russian Federation
Ключевые слова
alcohol dehydrogenase; virus DNA; virus RNA; adult; alcohol abuse; alcohol liver cirrhosis; alcoholism; allele; article; controlled study; disease marker; female; gene frequency; genotype; hepatitis B; hepatitis C; human; human tissue; major clinical study; male; priority journal; Russian Federation
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/305/