GC/MS analysis of aqueous ethanol solutions of drugs. Part 1. Menthol and p-aminobenzoic acid derivatives

Ajoint GC/MS analysis of aqueous and aqueous-ethanol solutions of some drugs including menthol, validol, benzocaine, novocaine, and menovazin has been performed using a Varian 3900/2100T (USA) instrument equipped with a Varian Factor Four VF-5ms capillary column. The structures of some impurities that were previously based on theoretical considerations are confirmed. Structural-analytical possibilities of the latest modification of the Varian GC/MS system with an ion-trap source are investigated. It is possible to obtain clear mass spectra even for low-intensity and partly overlapping chromatographic peaks using the given device combination. The results can be used for quality control of drugs based on the investigated compounds. © 2009 Springer Science+Business Media, Inc.

Редакторы
-
Издательство
-
Номер выпуска
8
Язык
Английский
Страницы
480-483
Статус
Опубликовано
Подразделение
-
Номер
-
Том
43
Год
2009
Организации
  • 1 Center for Instrumental Methods and Innovative Analytical Techniques and Materials, Peoples Friendship University, Moscow, Russian Federation
Ключевые слова
Benzocaine; Drugs; GC/MS analysis; Impurity chemical structure; Menovazin; Menthol; Novocaine; Validol
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/2935/