An efficient synthesis of isomeric 1-(1-Alkyl-1H-pyrazolyl) ethanones

A simple and versatile general method for the preparation of N-substituted 3-, 4-, or 5-acetylpyrazoles from corresponding acids via hydrolysis and decarboxylation of substituted diethyl [(1-alkyl-1H-pyrazolyl)carbonyl]malonates was developed. Title compounds were prepared in three steps without isolation of intermediates in 48-82% overall yield. © 2012 HeteroCorporation.

Авторы
Издательство
HeteroCorporation
Номер выпуска
6
Язык
Английский
Страницы
1422-1424
Статус
Опубликовано
Том
49
Год
2012
Организации
  • 1 G.S Petrov Institute of Plastics, Perovskiy Proezd 35, Moscow 111024, Russian Federation
  • 2 People's Friendship University of Russia, Moscow 117198, Russian Federation
Ключевые слова
3 acetylpyrazole derivative; 4 acetylpyrazole derivative; 5 acetylpyrazole derivative; pyrazole derivative; unclassified drug; article; chemical structure; decarboxylation; hydrolysis; isomer; reaction analysis; structure analysis; synthesis
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/2245/