Role of serotoninergic structures in coordination of electric activity in the gastroduodenal complex

Myoelectric activity in various portions of the stomach and duodenum in normal and after vagotomy and intravenous injection of serotonin adipinate was studied in acute experiments on cats. Vagotomy disturbed coordination of myoelectric activity in the stomach and duodenum. Intravenous injection of serotonin adipinate restored coordination and increased myoelectric activity in the stomach, particularly, in the pylorus. Under these conditions the pacemaker of myoelectric activity in the gastric corpus and autonomic regulation of the duodenum were preserved. Intravenous injection of serotonin adipinate most significantly changed myoelectric activity in the pylorus. Myoelectric activity in the cardia increased after vagotomy against the background of serotonin adipinate. Our findings suggest that serotoninergic structures maintain functional heterogeneity of digestive organs and coordinate their interrelationships.

Авторы
Bilibin D.P. 1, 2, 3 , Shevelev O.A. 1, 2, 3 , Khodorovich N.A. 1, 2, 3 , Zav'yalov A.V. 1, 2, 3 , Gorpinich A.B. 1, 2, 3 , Privalova I.L. 1, 2, 3 , Durneva O.M. 1, 2, 3
Редакторы
-
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
3
Язык
Английский
Страницы
229-231
Статус
Опубликовано
Подразделение
-
Номер
-
Том
133
Год
2002
Организации
  • 1 Russian University of People's Friendship, Russian Federation
  • 2 Kursk State Medical University, Russian Federation
  • 3 Orel State University, Russian Federation
Ключевые слова
Electric activity; Gastroduodenal complex; Serotoninergic structures
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/183/