The year 2021 was marked with a significant date – 100 years ago, brilliant radiobiologist and geneticist N.V. Timofeeff-Ressovsky started his scientific work. Among the new directions developed by him from 1921 to 1981 were physical biology, basic principles of genetic engineering, amplifier principle, and population radiobiology. It is noteworthy that many of his ideas were developed in the former Department of Radiation Genetics and General Radiobiology of the Institute of Medical Radiology in Obninsk, which is now called the Experimental Sector of the A. Tsyb Medical Radiological Research Centrе. Our work reveals the interconnections of Timofeeff-Ressovsky’s works with the activities of his contemporaries and productive ideas of today. © 2023, Akademkniga. All rights reserved.