Induction of antimeningitis immunity by synthetic peptides. III. Immunoactive synthetic fragments of the NspA protein from Neisseria meningitidis

Four potentially immunoactive peptide fragments of the NspA protein from the outer membrane of the bacterium Neisseria meningitidis were synthesized in order to create a synthetic vaccine against the meningococcal infection by the serogroup B bacterium. Mice of various lines were immunized with the free peptides nonconjugated with a protein carrier. All the synthetic peptides were shown to induce the production of the antipeptide antibodies in mice. A peptide capable of inducing a decrease in the number of bacteria in blood and the protection of infected animals from death was found in the experiments on the protection of the animals infected with two strains of the Neisseria meningitidis serogroup B.

Авторы
Koroev D.O.1 , Oboznaya M.B.1 , Zhmak M.N.1 , Volkova T.D.1 , Titova M.A.1 , Kotel'nikova O.V.1 , Lakhtina O.E.1 , Vol'pina O.M.1 , Nesmeyanov V.A.1 , Alliluev A.P. 2 , Ivanov V.T.1
Редакторы
-
Издательство
-
Номер выпуска
4
Язык
Русский
Страницы
296-297
Статус
Опубликовано
Подразделение
-
DOI
-
Номер
-
Том
28
Год
2002
Организации
  • 1 Shemyakin-Ovchinnikov Inst. B., Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, GSP Moscow, 117997, Russian Federation
  • 2 Inst. of Gen. and Clinical Pathology, Peoples' Friendship Univ. of Russia, ul. Miklukho-Maklaya 6, Moscow, 117997, Russian Federation
Ключевые слова
Bacteremia; Immunogenicity; Neisseria meningitidis; NspA; Protective activity; Synthetic peptides
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/150/