Suppression of the Antioxidant System and PI3K/Akt/mTOR Signaling Pathway in Cisplatin-Resistant Cancer Cells by Quercetin

We studied the effect of quercetin on ovarian adenocarcinoma SKOV-3 cell line and isogenic subline SKOV-3/CDDP resistant to the anticancer drug cisplatin. It was found that in resistant cells, quercetin in a concentration of 100 μM that causes a decrease in the cell viability suppressed the expression of genes encoding the key antioxidant enzymes (SOD2, CAT, GPX1, and HO-1), transcription factor Nrf2, and kinases of the PI3K/Akt/mTOR signaling pathway. In parental cells, quercetin, on the contrary, increased the expression of these genes. The results confirm the redox-dependent regulation induced by quercetin and its opposite nature in cisplatin-sensitive and cisplatin-resistant cancer cells.

Authors
Hasan A.A.Sh.1 , Kalinina E.V. 1 , Tatarskiy V.V.2 , Volodina Yu.L.2 , Petrova А.S. 1 , Novichkova M.D. 1 , Zhdanov D.D. 1 , Shtil A.A.2
Journal
Bulletin of Experimental Biology and Medicine
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
6
Language
English
Pages
760-764
Status
Published
Link
External link
DOI
10.1007/s10517-022-05626-9
Volume
173
Year
2022
Organizations
  • 1 Peoples’ Friendship University of Russia
  • 2 Laboratory of Tumor Cell Death, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
Keywords
drug resistance of tumor cells; gene expression; PI3K-AkT-mTOR signaling pathway; quercetin
Date of creation
27.04.2023
Date of change
03.05.2023
Short link
https://repository.rudn.ru/en/records/article/record/93487/
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