Materials.
MDPI AG.
Vol. 16.
2023.
3303 p.
Suppression of PI3K/Akt/mTOR Signaling Pathway and Antioxidant System and Reversal of Cancer Cells Resistance to Cisplatin under the Effect of Curcumin
The effect of curcumin on the resistance of SKOV-3 human ovarian adenocarcinoma cells to cisplatin was studied. It was found that curcumin induced “reversal” of cancer cells resistance, which was associated with suppression of the expression of genes encoding the key antioxidant enzymes (SOD1, SOD2, CAT, GPX1, and HO-1) and transcription factor Nrf2 and a decrease in the expression of genes encoding kinases of the PI3K/Akt/mTOR signaling pathway. The obtained results confirm the role of redox-dependent regulation in the “reversal” of cancer cells resistance to cisplatin.
Authors
Kalinina E.V.
1
,
Hasan A.A.Sh.1
,
Tatarskiy V.V.2
,
Volodina Yu.L.2
,
Petrova А.S.2
,
Novichkova M.D.
1
,
Zhdanov D.D.
1
,
Nurmuradov N.K.
1
,
Chernov N.N.
1
,
Shtil A.A.2
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
3
Language
English
Pages
371-375
Status
Published
Link
Volume
173
Year
2022
Organizations
- 1 Peoples’ Friendship University of Russia
- 2 Laboratory of Tumor Cell Death, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
Keywords
tumor cells drug resistance; gene expression; PI3K/AkT/mTOR signaling pathway; cisplatin
Date of creation
27.04.2023
Date of change
27.04.2023
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Other records
Bulletin of Experimental Biology and Medicine.
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук.
Vol. 173.
2022.
P. 760-764