Mesenchymal Stromal Cells as a Driver of Inflammaging

Life expectancy and age-related diseases burden increased significantly over the past few decades. Age-related conditions are commonly discussed in a very limited paradigm of depleted cellular proliferation and maturation with exponential accumulation of senescent cells. However, most recent evidence showed that the majority of age-associated ailments, i.e., diabetes mellitus, cardiovascular diseases and neurodegeneration. These diseases are closely associated with tissue nonspecific inflammation triggered and controlled by mesenchymal stromal cell secretion. Mesenchymal stromal cells (MSCs) are known as the most common type of cells for therapeutic approaches in clinical practice. Side effects and complications of MSC-based treatments increased interest in the MSCs secretome as an alternative concept for validation tests in regenerative medicine. The most recent data also proposed it as an ideal tool for cell-free regenerative therapy and tissue engineering. However, senescent MSCs secretome was shown to hold the role of ‘key-driver’ in inflammaging. We aimed to review the immunomodulatory effects of the MSCs-secretome during cell senescence and provide eventual insight into the interpretation of its beneficial biological actions in inflammaging-associated diseases.

Authors
Lyamina Svetlana1, 2 , Baranovskii Denis 1, 3, 4 , Kozhevnikova Ekaterina1 , Ivanova Tatiana1 , Kalish Sergey1, 2 , Sadekov Timur1 , Klabukov Ilya 3, 4 , Maev Igor1 , Govorun Vadim1, 2
Publisher
MDPI AG
Number of issue
7
Language
English
Pages
6372
Status
Published
Volume
24
Year
2023
Organizations
  • 1 Molecular Pathology of Digestion Laboratory, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Delegatskaya Str., 20/1, 127473 Moscow, Russia
  • 2 Scientific Research Institute for Systems Biology and Medicine, Nauchniy Proezd, 18, 117246 Moscow, Russia
  • 3 Peoples’ Friendship University of Russia
  • 4 National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia
Date of creation
30.03.2023
Date of change
30.03.2023
Short link
https://repository.rudn.ru/en/records/article/record/93376/
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