Regression of structural and functional alterations in the hypertrophic left ventricle as a result of a long-term correction of arterial pressure with ingibeis (chilasapril)

The regression of structural and functional alterations in the hypertrophic left ventricle was measured in the course of long-term correction of arterial pressure with a new inhibitor of angiotensin-converting enzyme ingibeis (chilasapril) in 23 patients with essential hypertension stage II-III. The results were for the most part obtained at echocardiography providing basic hemodynamic parameters and those of left ventricular diastolic function. Adaptability of the hypertrophic myocardium in response to physical loading was studied dynamically under isometric exercise test. The findings proved high efficacy of chilasapril in monotherapy of arterial hypertension. Long-term (6 months) therapy of left, ventricular hypertrophy provides regression of the latter and improves left ventricular diastolic function, pumping capacity. In the course of arterial hypertension correction relevant patients with associated coronary heart disease improved their condition, demonstrated less frequent ECG changes indicative of ischemia.

Authors
Gurochkin A.B.1 , Ivleva Ya.A. , Kobalava Zh.D. , Moiseev V.S. 1
Editors
-
Publisher
-
Number of issue
9
Language
Russian
Pages
46-49
Status
Published
Department
-
DOI
-
Number
-
Volume
66
Year
1994
Organizations
  • 1 Kafedra Obshchej i Klin. Farmakol., Ross. Universitet Druzhby Narodov, Moskva, Russian Federation
Keywords
chilasapril; dipeptidyl carboxypeptidase; dipeptidyl carboxypeptidase inhibitor; unclassified drug; cilazapril; article; blood pressure; clinical article; clinical trial; drug effect; electrocardiogram; essential hypertension; exercise test; heart left ventricle function; heart left ventricle hypertrophy; human; adult; comparative study; echocardiography; echography; female; heart left ventricle hypertrophy; hypertension; male; pathophysiology; remission; time; Adult; Blood Pressure; Cilazapril; Comparative Study; Echocardiography; English Abstract; Female; Human; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Age; Remission Induction; Time Factors; Ventricular Function, Left
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/920/