Glycerol Valorization towards a Benzoxazine Derivative through a Milling and Microwave Sequential Strategy

Glycerol and aminophenol intermolecular condensation has been investigated through a milling and microwave-assisted sequential strategy, towards the synthesis of a benzoxaxine derivative. Mechanochemical activation prior to the microwave-assisted process could improve the probability of contact between the reagents, and greatly favors the higher conversion of aminophenol. At the same time, following a mechanochemical–microwave sequential approach could tune the selectivity towards the formation of a benzoxazine derivative, which could find application in a wide range of biomedical areas. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Authors
Torres-Pastor M.Á.1 , Espro C.2 , Selva M.3 , Perosa A.3 , Reyes A.A.R.1 , Osman S.M.4 , Luque R. 1, 4, 5 , Rodríguez-Padrón D. 2
Journal
Molecules
Publisher
MDPI AG
Number of issue
3
Language
English
Status
Published
Link
External link
DOI
10.3390/molecules27030632
Number
632
Volume
27
Year
2022
Organizations
  • 1 Grupo FQM-383, Departamento de Química Orgánica, Universidad de Cordoba, Cordoba, 14014, Spain
  • 2 Dipartimento di Ingegneria, Università di Messina, Messina, 98100, Italy
  • 3 Dipartimento di Scienze Molecolari e Nanosistemi, UniversitàCa’ Foscari di Venezia, Venezia, 30123, Italy
  • 4 Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia
  • 5 Scientific Center for Molecular Design and Synthesis of Innovative Compounds for the Medical Industry, People’s Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
Keywords
Benzoxazine derivative; Glycerol valorization; Microwave irradiation; Milling
Date of creation
06.07.2022
Date of change
06.07.2022
Short link
https://repository.rudn.ru/en/records/article/record/83896/
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