Plants. Vol. 11. 2022.
Synthesis of Selenium-Containing Chitosan Derivatives and Their Antibacterial Activity
Abstract: The interaction of chitosan with 3-(chloromethyl)-[1,2,4]selendiazole[4,5-a]pyridin-4 bromide results in water-soluble, selenium-containing, cationic chitosan derivatives. Derivatives of chitosan with degrees of substitution of 0.15, 0.45, and 0.65 were obtained. These derivatives are characterized by a pronounced in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli, and the antibacterial activity of the derivatives increases with an increase in their degree of substitution. The antibacterial activity of the highly substituted derivative is comparable to that of the conventional antibiotics ampicillin and gentamicin. © 2022, The Author(s).
Authors
Egorov A.R. 1 , Artemjev A.A. 1 , Kozyrev V.A. 1 , Sikaona D.N. 1 , Rubanik V.V. 2 , Rubanik Jr V.V. , Kritchenkov I.S. 3 , Yagafarov N.Z. 1, 4 , Khubiev O.M. 1 , Tereshina T.A. 1 , Kultyshkina E.K. 1 , Medjbour B. 1 , Khrustalev V.N. 1, 5 , Kritchenkov A.S. 1, 2
Issue number
2
Language
English
Pages
132-135
State
Published
Link
Volume
58
Year
2022
Organizations
- 1 Peoples’ Friendship University of Russia (RUDN University), Faculty of Science, Moscow, 117198, Russian Federation
- 2 Institute of Technical Acoustics, National Academy of Sciences of Belarus, Vitebsk, 210009, Belarus
- 3 St. Petersburg State University, St. Petersburg, 199034, Russian Federation
- 4 Pirogov Russian National Research Medical University, Moscow, 117997, Russian Federation
- 5 Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russian Federation
Keywords
antibacterial activity; chitosan; heterocycles; selenium
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