Community-acquired pneumonia in HIV patients

The objective: To study the frequency and nature of community-acquired pneumonia (CAP) in HIV patients. Subjects and methods: The continuous longitudinal retrospective study of all cases of respiratory diseases among HIV patients (n = 185), who received in-patient treatment in the therapy department. Results. CAP was diagnosed in 38.4% (n = 71) of patients and it was the most frequent respiratory disease among HIV patients. The median CD4 count in CAP made 197.5 cells/μL, 9.1% of patients received antiretroviral therapy before hospital admission. 74.7% of CAP patients (n = 53) had lesions disseminated to several lobes. Laboratory parameters revealed in severe CAP (leukocytosis > 12 × 109/L, leukopenia < 4.0 × 109/L and thrombocytopenia < 100 × 1012/L) were associated with the degree of immunodeficiency and did not depend on the infiltration dissemination (p > 0.05). Bacteremia in CAP was detected in 20.8% of patients and it was associated with the failure of standard empiric antibiotic therapy (p < 0.05). 9.9% of CAP patients (n = 7) were diagnosed with polymicrobial infection. Lethal outcomes of CAP were recorded in 5.6% of cases (n = 4), all with severe immunosuppression (the median of CD4 count was 5 cells/μL), 2 cases had bilateral subtotal CAP and 2 suffered from polymicrobial infection. © 2021 New Terra Publishing House. All rights reserved.

Authors
Viktorova I.B. 1 , Zimina V.N. 2, 3 , Dadyka I.V.4 , Andreeva I.V.4 , Golovina I.A.4 , Chuzhikova E.P.4
Publisher
New Terra Publishing House
Number of issue
4
Language
Russian
Pages
22-28
Status
Published
Volume
99
Year
2021
Organizations
  • 1 Novokuznetsk State Institute for Doctors' Professional Development, Branch of Russian Medical Academy of Continuing Professional Education, Novokuznetsk, Russian Federation
  • 2 Peoples' Friendship University of Russia, Moscow, Russian Federation
  • 3 National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Moscow, Russian Federation
  • 4 Novokuznetsk Branch of Kemerovo Regional Clinical Cardiology Dispensary Named after Academician L. S. Barbarash, Novokuznetsk, Russian Federation
Keywords
Community-acquired pneumonia; HIV infection; Immunosuppression
Date of creation
16.12.2021
Date of change
16.12.2021
Short link
https://repository.rudn.ru/en/records/article/record/77230/
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