Predicting of fentanyl-associated neurotoxicity in pancreatic cancer with clical, genetic model [Прогнозирование фентанил-ассоциированной нейротоксичности у больных с раком поджелудочной железы с помощью клинико-генетической модели]

Aim. To develop a model for the implementation of opioid - associated neurotoxicity in patients with pancreatic cancer based on an analysis of the relationship of clinical and genetic factors. Materials and methods. In 45 patients with pancreatic cancer, 54 clinical and genetic factors were studied for predicting the implementation of opioid-associated neurotoxicity, receiving a transdermal form of fentanyl. Results. A clinical genetic model of the implementation of opioid - associated neurotoxicity in patients with pancreatic cancer was developed using the example of a transdermal form of fentanyl Conclusion. The clinical genetic model for predicting the risk of opioid-associated neurotoxicity in patients with pancreatic cancer is important from the perspective of personalized medicine. © 2021 Global Media Tekhnologii. All rights reserved.

Authors
Bobrova O.P. 1, 2 , Shnayder N.A. 3 , Petrova M.M.1 , Zobova S.N. 1 , Dykhno Y.A.1, 2 , Zyryanov S.K. 4 , Bobrov A.V.5 , Nasyrova R.F. 3 , Lipinsky L.V.5 , Polyakova A.S.5 , Melnikova O.D.5
Journal
Экспериментальная и клиническая гастроэнтерология
Publisher
Общество с ограниченной ответственностью Глобал медиа технологии
Number of issue
3
Language
Russian
Pages
136-145
Status
Published
Link
External link
DOI
10.31146/1682-8658-ecg-187-3-136-145
Volume
187
Year
2021
Organizations
  • 1 Prof. V. F. Voino - Yasenetsky Krasnoyarsk State Medical University, 1, P. Zeleznyaka Str., Krasnoyarsk, 660022, Russian Federation
  • 2 Krasnoyarsk Regional Clinical Oncology Center named after A.I. Kryzhanovskiy, 16, 1st Smolenskaya Str., Krasnoyarsk, 660133, Russian Federation
  • 3 V.M. Bekhterev national research medical center for psychiatry and neurology, The Ministry of Health of the Russian Federation, BekhterevaStr., St. Petersburg, 192019, Russian Federation
  • 4 Peoples' Friendship University of Russia, 6, Miklouho - Maclay Str., Moscow, 117198, Russian Federation
  • 5 Reshetnev Siberian State University of Science and Technology, 31, Prospect named after the newspaper Krasnoyarsk worker, Krasnoyarsk, 660037, Russian Federation
Keywords
Fentanyl TTS; Modeling; Neurotoxicity; Opioids; Pancreatic cancer; Pharmacogenetics; Sedation
Date of creation
16.12.2021
Date of change
16.12.2021
Short link
https://repository.rudn.ru/en/records/article/record/77224/
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