Predicting of fentanyl-associated neurotoxicity in pancreatic cancer with clical, genetic model [Прогнозирование фентанил-ассоциированной нейротоксичности у больных с раком поджелудочной железы с помощью клинико-генетической модели]

Aim. To develop a model for the implementation of opioid - associated neurotoxicity in patients with pancreatic cancer based on an analysis of the relationship of clinical and genetic factors. Materials and methods. In 45 patients with pancreatic cancer, 54 clinical and genetic factors were studied for predicting the implementation of opioid-associated neurotoxicity, receiving a transdermal form of fentanyl. Results. A clinical genetic model of the implementation of opioid - associated neurotoxicity in patients with pancreatic cancer was developed using the example of a transdermal form of fentanyl Conclusion. The clinical genetic model for predicting the risk of opioid-associated neurotoxicity in patients with pancreatic cancer is important from the perspective of personalized medicine. © 2021 Global Media Tekhnologii. All rights reserved.